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A cardiac glycoside with cardiotonic and antiarrhythmic activities inhibits Na /K -ATPase in an isoform-specific biphasic manner with IC50 values of 0.298 and 410 UM for the high- and low affinity human erythrocyte isoenzymes respectively and 1.18 and 28.5 UM for the high- and low affinity porcine cerebral cortex isoenzymes respectively increases contractility and rhythmicity in isolated guinea pig heart in a concentration-dependent manner a degradation product of digoxin
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A glucocorticoid receptor agonist and an active metabolite of beclomethasone dipropionate binds to the glucocorticoid receptor (IC50 3 nM) inhibits PMA-induced glucocorticoid receptor transrepression as well as induces transactivation of the glucocorticoid receptor in CV-1 cells expressing the human receptor inhibits LPS-induced increases in IL-6 IL-8 and TNF-a levels in primary human lung macrophages from patients with COPD (IC50s 0.36 2.04 and 0.21 nM respectively)
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